Table 4.
Values of human fraction absorbed (F a) using in‐house PBPK or ADAM model within Simcyp® and based on permeability derived from physicochemical properties
| Predicted human F a | ||
|---|---|---|
| In‐house PBPK | ADAM model within Simcyp® | |
| Alprazolam | 1 | 1 |
| Alprenolol | 1 | 1 |
| Chlorpromazine | 1 | 1 |
| Clozapine | 1 | 1 |
| Cyclosporine | 0.09 | 0.39 |
| Diltiazem | 1 | 1 |
| Domperidone | 1 | 1 |
| Erythromycin | 0.04 | 0.02 |
| Felodipine | 1 | 1 |
| Flumazenil | 1 | 1 |
| Itraconazole | 1 | 0.97 |
| Lidocaine | 1 | 1 |
| Metoprolol | 1 | 0.96 |
| Midazolam | 1 | 1 |
| Mirtazapine | 1 | 1 |
| Nalbuphine | 0.73 | 0.67 |
| Nicardipine | 1 | 1 |
| Nifedipine | 1 | 0.89 |
| Nimodipine | 1 | 0.72 |
| Nisoldipine | 0.21 | 0.36 |
| Nitrendipine | 1 | 0.67 |
| Omeprazole | 1 | 1 |
| Saquinavir | 0.2 | 0.18 |
| Sildenafil | 0.93 | 0.91 |
| Tacrolimus | 0.49 | 0.52 |
| Tolterodine | 1 | 1 |
| Triazolam | 1 | 1 |
| Venlafaxine | 1 | 1 |
| Verapamil | 1 | 1 |
| Zolmitriptan | 1 | 0.96 |
| Zolpidem | 1 | 1 |