Table 8.

Summary of F _g values predicted by ADAM, Q _gut, Competing Rates models using in vitro HLM CL _int and in vivo rat F _g values estimated by indirect or PBPK approaches

		F g (ADAM, in vitro CL int)	F g (Q gut, in vitro CL int)	F g (Competing Rates, in vitro CL int)	Rat in vivo F g
1	Alprazolam	0.98	0.97	0.99	1
2	Alprenolol	0.92	1	1	0.09
3	Chlorpromazine	0.82	0.98	1	0.04
4	Clozapine	0.96	0.96	0.98	1
5	Cyclosporine				0.37
6	Diltiazem	0.92	0.89	0.95	0.13
7	Domperidone	0.66	0.39	0.49	0.80
8	Erythromycin				0.28
9	Felodipine	0.71	0.59	0.77	0.42
10	Flumazenil	0.94	0.85	0.90	1
11	Itraconazole				0.39
12	Lidocaine	0.97	0.97	0.98	0.03
13	Metoprolol	0.99	0.98	0.99	0.49
14	Midazolam	0.64	0.54	0.83	0.86
15	Mirtazapine	0.99	0.99	1	0.15
16	Nalbuphine	0.99	0.82	0.83	0.01
17	Nicardipine				1
18	Nifedipine	0.83	0.36	0.40	0.55
19	Nimodipine	0.38	0.07	0.09	0.23
20	Nisoldipine	0.40	0.06	0.07	0.06
21	Nitrendipine				0.14
22	Omeprazole	0.99	0.97	0.98	0.35
23	Saquinavir	0.48	0.00	0.00	0.13
24	Sildenafil	0.92	0.49	0.53	0.36
25	Tacrolimus				0.16
26	Tolterodine	0.63	0.89	0.97	1
27	Triazolam				0.28
28	Venlafaxine	0.99	1	1	0.65
29	Verapamil	0.49	0.39	0.67	0.1
30	Zolmitriptan				0.65
31	Zolpidem	0.99	0.98	0.99	0.35