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| Ziconotide | Opioid | |
|---|---|---|
| Death from Overdose | no | yes |
| Withdrawal Symptoms if abrupt cessation | no | yes |
| Need for planned 23 hour observation following trial and implant | no (if no neurologic signs or symptoms post 8 hours from dosing) | yes |
| Need for accurate dosing | yes | yes |
| Granulomagenic | no | yes* |
*fentanyl may not be granulomagenic.
