Table 2.
Cox proportional hazards model including individual donor characteristics and recipient characteristics to identify independent predictors of mortality and graft failure.
| Risk of Mortality | Risk of Graft Failure | |
|---|---|---|
| Hazard Ratio (95% CI) | Hazard Ratio (95% CI) | |
| Donor Factors | ||
| Age (Ref: <40) | ||
| 40–64 | 0.99 (0.84–1.18) | 1.07 (0.91–1.27) |
| 65–74 | 1.05 (0.81–1.36) | 1.13 (0.88–1.45) |
| ≥75 | 1.15 (0.77–1.71) | 1.37 (0.95–1.97) |
| Sex (Ref: Male) | 1.01 (0.87–1.17) | 1.04 (0.91–1.20) |
| Race (Ref: White) | ||
| African American | 0.87 (0.72–1.05) | 0.97 (0.81–1.16) |
| Hispanic | 1.08 (0.84–1.39) | 1.10 (0.86–1.40) |
| Other | 1.04 (0.69–1.57) | 0.99 (0.66–1.48) |
| Cause of Death (Ref: Other) | ||
| CVA/Stroke | 1.09 (0.91–1.32) | 1.11 (0.93–1.33) |
| Head Trauma | 0.84 (0.68–1.02) | 0.91 (0.75–1.09) |
| Body Mass Index- kg/m2 (Ref: <25) | ||
| 25–29 | 1.00 (0.85–1.17) | 1.00 (0.86–1.17) |
| 30–34 | 0.93 (0.76–1.14) | 0.92 (0.75–1.12) |
| 35–39 | 1.15 (0.88–1.50) | 1.14 (0.89–1.47) |
| ≥40 | 1.17 (0.83–1.66) | 1.04 (0.74–1.46) |
| Cold Ischemic Time (Ref: <6 hours) | ||
| ≥6 hours | 1.07 (0.93–1.23) | 1.14 (0.99–1.30) |
| Recipient Factors | ||
| Age (Ref: <50) | ||
| 50–64 | 1.27 (1.01–1.59)** | 1.17 (0.95–1.44) |
| ≥65 | 2.03 (1.58–2.59)** | 1.74 (1.39–2.19)** |
| Sex (Ref: Male) | 0.95 (0.83–1.10) | 0.94 (0.83–1.08) |
| Race (Ref: White) | ||
| African American | 0.95 (0.59–1.51) | 1.06 (0.69–1.62) |
| Hispanic | 0.87 (0.68–1.13) | 0.92 (0.72–1.17) |
| Other | 0.70 (0.41–1.19) | 0.69 (0.40–1.14) |
| MELD (Ref: <20) | ||
| 20–29 | 1.13 (0.96–1.34) | 1.12 (0.96–1.31) |
| 30–39 | 1.82 (1.51–2.21)** | 1.71 (1.42–2.06)** |
| ≥40 | 1.92 (1.43–2.58)** | 1.67 (1.25–2.23)** |
| Body Mass Index- kg/m2 (Ref: <25) | ||
| 25–29 | 0.71 (0.56–0.89)** | 0.71 (0.56–0.88) |
| 30–34 | 0.71 (0.57–0.89)** | 0.76 (0.61–0.94) |
| 35–39 | 0.75 (0.59–0.95)** | 0.79 (0.63–0.99)** |
| ≥40 | 0.73 (0.54–0.98)** | 0.78 (0.59–1.03) |
| History of Diabetes (Ref: No) | ||
| Yes | 1.26 (1.09–1.46)** | 1.21 (1.06–1.39)** |
| Unknown | 0.85 (0.48–1.52) | 1.10 (0.67–1.79) |
| Waitlist Time (Ref: <3 months) | ||
| 3–6 months | 1.05 (0.87–1.28) | 1.08 (0.89–1.29) |
| 7–9 months | 1.04 (0.80–1.35) | 1.09 (0.85–1.40) |
| >9 months | 1.08 (0.90–1.30) | 1.10 (0.93–1.31) |
| Region (Ref: Southeast) | ||
| Southwest | 0.89 (0.62–1.30) | 0.80 (0.55–1.15) |
| West | 0.82 (0.62–1.30) | 0.81 (0.62–1.07) |
| Northwest | 0.59 (0.29–1.21) | 0.54 (0.26–1.11) |
| Midwest | 1.02 (0.84–1.25) | 1.06 (0.88–1.29) |
| Northeast | 1.17 (0.96–1.43) | 1.13 (0.94–1.36) |
**
designates significant value