Table 2.
Males | Females | |||||
---|---|---|---|---|---|---|
Dabigatran 150 mg twice daily | Rivaroxaban 20 mg once daily | Warfarin | Dabigatran 150 mg twice daily | Rivaroxaban 20 mg once daily | Warfarin | |
Number of patients | 7,618 | 7,618 | 7,618 | 11,031 | 11,031 | 11,031 |
Stroke | 1.53 (1.31 – 1.81)(69) | 0.97 (0.66 – 1.24)(48) | 1.42 (1.29 – 1.77)(68) | 1.44 (1.21 – 2.01) (107) | 1.67 (1.20 – 2.11) (119) | 1.75 (1.41 – 2.59) (130) |
Any hemorrhage | 3.16 (2.61 – 3.69)(142) | 3.86 (3.66 – 4.48)(189) | 4.23 (3.81 – 4.78) (202) | 3.82 (3.10 – 4.27) (282) | 5.18 (4.70 – 5.99) (327) | 3.90 (3.01 – 4.36) (288) |
GI hemorrhage (GIH) | 2.73 (2.15 – 3.27) (123) | 3.30 (3.09 – 4.01) (162) | 3.24 (2.83 – 3.82) (155) | 3.49 (2.88 – 3.89) (258) | 4.55 (3.98 – 5.24) (288) | 2.89 (2.13 – 3.61) (214) |
Intra-cranial Hemorrhage (ICH) | 0.13 (0.03 – (0.29)(6) | 0.26 (0.08 – 0.58) (13) | 0.44 (0.33 – 0.91) (21) | 0.21 (0.01 – 0.33) (16) | 0.38 (0.10 – 0.96) (24) | 0.54 (0.37 – 1.01) (40) |
Other Non-GI hemorrhage | 0.49 (0.10 – 0.77) (22) | 0.55 (0.15 – 0.83) (27) | 1.02 (0.87 – 1.67) (49) | 0.35 (0.06 – 0.51) (26) | 0.66 (0.53 – 0.81) (42) | 1.07 (0.90 – 1.77) (80) |