Figure 2. DP1 knockout augments DSS‐induced colitis in mice.

• A
  PCR analysis of tail genomic DNA from DP1^−/−, DP2^−/−, and WT mice.
• B–D
  Body weight loss (B) and disease activity index (C), and colon length (D) of DP1^−/−, DP2^−/−, and WT mice in response to DSS challenge. Scale bar: 1 cm.
• E
  H&E staining of histological sections in the distal colon from the mice administered with DSS for 6 days. Scale bars: 100 μm. Graphs represent overall histology score.
• F
  Survival rates of DSS‐challenged DP1^−/−, DP2^−/− mice, and WT controls.

Data information: Data are shown as mean ± SEM. Data are representative of three independent experiments. (B–D) Statistical significance was determined using unpaired Student's t‐tests. **P < 0.01 compared with WT. Left panel: WT, n = 8; DP1^−/−, n = 8. Right panel: WT, n = 7; DP2^−/−, n = 8. (F) Survival rate was compared using the log‐rank test. *P < 0.05, compared with WT; n = 10.