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. 2017 Mar 27;9(5):571–588. doi: 10.15252/emmm.201606987

Figure EV5. PGD2 infusion ameliorates DSS‐induced colitis in mice.

Figure EV5

  • A–C
    Effect of PGD2 treatment on body weight loss (A), disease activity index (B), and colon length (C, centimeter) of WT mice in response to DSS challenge.
  • D
    Effect of PGD2 on Evan's blue extravasation in the colonic mucosa from WT mice.
  • E
    Effect of PGD2 on DSS‐induced epithelial cell apoptosis in WT mice. Scale bars: 100 μm. The arrows indicate TUNEL+ cells.
  • F
    Effect of PGD2 on colonic macrophage infiltration in DSS‐challenged WT mice. Scale bars: 100 μm. The arrows indicate CD301+CD68+ cells.
Data information: All mice were sacrificed at day 9. Data are shown as mean ± SEM. Statistical significance was determined using unpaired Student's t‐tests. (A–C) # P < 0.05, ## P < 0.01 vs. vehicle; n = 7. (D) ## P < 0.01 compared with vehicle; n = 7. (E) # P < 0.05 compared with vehicle; vehicle, n = 5; PGD2, n = 7. (F) ## P < 0.01 compared with vehicle; n = 5.