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. 2017 Apr 4;9(5):589–604. doi: 10.15252/emmm.201607027

Figure EV3. IMQ‐induced psoriasis‐like skin disease is attenuated in RIG‐I−/− mice.

Figure EV3

  • A
    Representative photographs of the ears of WT mice (left panel) and RIG‐I−/− mice (right panel) after administration of imiquimod (IMQ) for 7 days, n = 4 per group.
  • B
    The ear thickness of WT and RIG‐I−/− mice on the indicated day presented relative to day 0. Significant differences are indicated: one‐way ANOVA, n = 4 per group (mean ± SEM).
  • C
    Representative H&E staining of the ears treated as in (A), n = 4 per group. Scale bar: 200 μm.
  • D
    Acanthosis of WT and RIG‐I−/− mice treated with imiquimod. Significant differences are indicated: two‐tailed Student's t‐test, n = 5 per group (mean ± SEM).
  • E
    Representative immunostaining of Ki67 in ear skin derived from WT and RIG‐I−/− mice treated with imiquimod, n = 5 per group. Scale bar: 100 μm.
  • F
    Quantitation of Ki67+ cells in ear skin derived from WT and RIG‐I−/− mice treated with imiquimod. Significant differences are indicated: two‐tailed Student's t‐test, n = 5 per group (mean ± SEM).
  • G, H
    ELISA detection of IL‐23p19 (G) and IL‐17 (H) protein levels in supernatants of ear skin homogenates derived from indicated groups. Significant differences are indicated: two‐tailed Student's t‐test, n = 3–4 per group (mean ± SEM).