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. 2017 Apr 4;9(5):589–604. doi: 10.15252/emmm.201607027

Figure 5. RIG‐I expression in haematopoietic cells is critical for IL‐23‐induced psoriasis‐like skin inflammation.

Figure 5

  • A
    Lethally irradiated WT mice were adoptively transferred with WT or RIG‐I−/− bone marrow cells, and the generated chimeric mice were subjected to IL‐23‐induced psoriasis‐like skin inflammation. Graph represents the ear thickness of WT recipient mice on the indicated day relative to day 0. Significant differences are indicated: P < 0.0001, one‐way ANOVA, n = 5 per group (mean ± SEM).
  • B, C
    Representative H&E staining and Ki67 immunostaining of the ears derived from indicated groups, n = 5 per group. Scale bar: 50 μm.
  • D
    Acanthosis of WT BM to WT recipients (WT BM‐WT) or RIG‐I−/− BM to WT recipients (RIG‐I−/− BM‐WT) treated with IL‐23. Significant differences are indicated: two‐tailed Student's t‐test, n = 5 per group (mean ± SEM).
  • E
    Dermal cellular infiltrates of WT BM‐WT or RIG‐I−/− BM‐WT mice treated with IL‐23. Significant differences are indicated: two‐tailed Student's t‐test, n = 5 per group (mean ± SEM).