Figure EV5. Schematic diagram of how the antiviral signaling mediates psoriasis pathogenesis.

In genetically predisposed individuals, the virus infection causes the activation of TLR‐7/8 and/or RIG‐I, and subsequently triggers IL‐23 release by CD11c⁺ DCs via the NF‐κB pathway. Genetic mutations in NF‐κB‐related genes result in an impaired negative regulation of its proinflammatory activity accompanied by uncontrolled IL‐23 release, thus leading to psoriasis.