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. 2017 Mar 10;9(5):605–621. doi: 10.15252/emmm.201607204

Figure 3. TFE3 regulates lipid catabolism.

Figure 3

  • A
    Body size and tissues' gross appearance from WT and Tfe3 KO mice after 1 month of high‐fat diet (HFD).
  • B
    Body weight gained over time in control and Tfe3 KO mice fed a HFD for 18 weeks (n = 6 per group). Data are presented as mean ± SEM. ANOVA test followed by post hoc Bonferroni test: ***P < 0.001.
  • C
    Visceral fat and lean mass from mice with the indicated genotypes after 1 month on HFD (n = 5 per group). Data are presented as mean ± SEM. Student's two‐tailed t‐test: **P = 0.0041.
  • D
    Respiratory exchange ratio (RER; VCO2/VO2) in WT (black line) and Tfe3 KO (red line) mice after 1 month of HFD (n = 5 per group). Grey areas indicate dark periods (6 PM to 6 AM). Data are presented as mean ± SEM.
  • E
    Bar graph represents RER average values during day and night (n = 5 per group). Data are presented as mean ± SEM. Student's two‐tailed t‐test: day *P = 0.0149; night *P = 0.0270.
  • F
    Energy expenditure (EE) normalized for body weight in WT (black line) and Tfe3 KO mice (red line) after 1 month of HFD (n = 5 per group). Grey areas indicate dark periods (6 PM to 6 AM). Data are presented as mean ± SEM.
  • G
    Bar graph represents average EE values during day and night (n = 5 per group). Data are presented as mean ± SEM. Student's two‐tailed t‐test: day *P = 0.0485; night *P = 0.0227.
  • H
    Liver triglycerides (TG) levels in WT and Tfe3 KO mice after 18 weeks of HFD (n = 5 per group). Dashed line indicates WT fed a chow diet. Data are presented as mean ± SEM. Student's two‐tailed t‐test: ****P < 0.0001.
  • I, J
    H&E, Oil Red O staining and EM images of liver sections (I) and H&E staining of eWAT, BAT and muscle sections (J) from Tfe3 KO and control mice fed a HFD for 18 weeks (scale bars liver, eWAT, BAT: 50 μm; scale bars muscle: 20 μm).