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. 2016 Dec 5;23(3):549–553. doi: 10.1002/chem.201605068

Table 1.

Optimization of the Ru‐catalyzed C−H arylation of 1 a with 2 a.

graphic file with name CHEM-23-549-g003.jpg
Entry Ru Solvent Additive 3 aa[a]
1 [RuCl2(p‐cymene)]2 1,4‐dioxane   2
2 [Ru(tBuCN)6](BF4)2 1,4‐dioxane   7
3 [Ru(tBuCN)6](BF4)2 tBuCN   41
4 [Ru(tBuCN)6](BF4)2 tBuCN KOPiv 51
5 [Ru(tBuCN)6](BF4)2 tBuCN KOC(CF3)3 61
6[b] [Ru(tBuCN)6](BF4)2 tBuCN KOC(CF3)3 >99
7[b,c] [Ru(tBuCN)6](BF4)2 tBuCN KOC(CF3)3 >99

[a] Yield determined by 1H‐NMR using 1,3‐dinitrobenzene as internal standard. [b] Reaction carried out at 140 °C. [c] [Ru(tBuCN)6](BF4)2 (3 mol %), tBuCN (8 equiv).