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. 2016 Dec 5;23(3):549–553. doi: 10.1002/chem.201605068

Table 3.

Scope of the Ru‐catalyzed arylation of benzoic acids 1 b–1 x with 4‐iodoanisole 2 a.[a]

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[a] Reaction conditions A: 1 b–n (0.3 mmol), 2 a (2.0 equiv), [Ru(tBuCN)6](BF4)2 (3 mol %), K2CO3 (2.0 equiv), KOC(CF3)3 (1.0 equiv) and tBuCN (8.0 equiv) stirred under Ar in a closed vessel at 140 °C for 16 h. Yields are of pure, isolated products. Reaction conditions B: 1 o–z (0.3 mmol), 2 a (4.0 equiv), [Ru(tBuCN)6](BF4)2 (6 mol %), K2CO3 (3.0 equiv), KOC(CF3)3 (1.5 equiv), tBuCN (12.0 equiv) and H2O (3.0 equiv) stirred under Ar in a closed vessel at 140 °C for 24 h. Yields are of pure, isolated products. [b] Isolated as the corresponding methyl ester after derivatization with MeI. [c] [Ru(tBuCN)6](BF4)2 (6 mol %). [d] Reaction time 3 h. [e] Yield evaluated by 1H NMR with 1,3‐dinitrobenzene as internal standard. [f] [Ru(tBuCN)6](BF4)2 (10 mol %). [g] Reaction time 1 h. [h] Reaction time 12 h, no H2O was added. [i] Reaction time 4 h.