Table 3.
Adverse events by age subgroup
| Age <70 years | Age ≥70 years | |||
|---|---|---|---|---|
| Carfilzomib group (n = 289) | Control group (n = 277) | Carfilzomib group (n = 103) | Control group (n = 112) | |
| Any‐grade AE, n (%) | 278 (96·2) | 267 (96·4) | 102 (99·0) | 111 (99·1) |
| Grade ≥3 AE, n (%) | 236 (81·7) | 215 (77·6) | 92 (89·3) | 99 (88·4) |
| Grade ≥3 AEs reported in ≥5% of patients in any subgroup, n (%) | ||||
| Neutropenia | 78 (27·0) | 77 (27·8) | 38 (36·9) | 26 (23·2) |
| Anaemia | 45 (15·6) | 44 (15·9) | 25 (24·3) | 23 (20·5) |
| Thrombocytopenia | 44 (15·2) | 31 (11·2) | 21 (20·4) | 17 (15·2) |
| Pneumonia | 33 (11·4) | 25 (9·0) | 16 (15·5) | 16 (14·3) |
| Hypophosphatemia | 26 (9·0) | 7 (2·5) | 7 (6·8) | 11 (9·8) |
| Hypokalaemia | 21 (7·3) | 12 (4·3) | 16 (15·5) | 7 (6·3) |
| Fatigue | 16 (5·5) | 13 (4·7) | 14 (13·6) | 12 (10·7) |
| Hyperglycaemia | 12 (4·2) | 11 (4·0) | 8 (7·8) | 7 (6·3) |
| Asthenia | 7 (2·4) | 5 (1·8) | 7 (6·8) | 3 (2·7) |
| Hypertension | 11 (3·8) | 5 (1·8) | 6 (5·8) | 2 (1·8) |
| Leucopenia | 10 (3·5) | 9 (3·2) | 2 (1·9) | 7 (6·3) |
| Rash | 3 (1·0) | 0 | 2 (1·9) | 6 (5·4) |
| Grade ≥3 AEs of interest | ||||
| Cardiac failurea | 6 (2·1) | 5 (1·8) | 9 (8·7) | 2 (1·8) |
| Ischaemic heart diseaseb | 8 (2·8) | 7 (2·5) | 5 (4·9) | 1 (0·9) |
| Pulmonary embolism | 7 (2·4) | 8 (2·9) | 5 (4·9) | 1 (0·9) |
| Acute renal failurec | 9 (3·1) | 6 (2·2) | 4 (3·9) | 6 (5·4) |
AE, adverse event.
The category of cardiac failure included (in descending order of frequency) cardiac failure, congestive cardiac failure, pulmonary oedema, hepatic congestion, cardiopulmonary failure, acute pulmonary oedema, acute cardiac failure and right ventricular failure.
The category of ischaemic heart disease included (in descending order of frequency) angina pectoris, myocardial infarction, acute myocardial infarction, increased blood creatinine phosphokinase, coronary artery disease, myocardial ischaemia, coronary artery occlusion, increased troponin, increased troponin T, acute coronary syndrome, abnormal cardiac stress test, cardiomyopathy stress, unstable angina, coronary artery stenosis, abnormal electrocardiogram ST‐T segment and abnormal electrocardiogram T wave.
The category of acute renal failure included (in descending order of frequency) acute renal failure, renal failure, renal impairment, azotemia, oliguria, anuria, toxic nephropathy and pre‐renal failure.