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Inhibiting the hedgehog (HH) signaling pathway with vismodegib is illustrated. Binding of an HH protein to the transmembrane receptor patched 1 (PTCH1) prevents PTCH1‐mediated inhibition of signaling by the transmembrane protein smoothened (SMO), leading to activation of the GLI family of transcription factors and the regulation of target genes. Vismodegib inhibits the HH pathway by binding to SMO.
