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. 2016 Nov 15;57(5):616–626. doi: 10.1002/jcph.840

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© 2016, The Authors. The Journal of Clinical Pharmacology published by Wiley Periodicals, Inc. on behalf of American College of Clinical Pharmacology

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Schematic of the PK/PD model structure. Abbreviations: I_max, maximal inhibition; IC₅₀, PCSK9 concentration associated with half‐maximal inhibition; k_a, absorption rate constant; k_el, elimination rate constant; k_syn, PCSK9 production rate constant; k_deg, PCSK9 elimination rate constant; K_D, dissociation constant; k_int, evolocumab‐PCSK9 complex elimination rate constant; k_in, LDL‐C production rate constant; k_out, LDL‐C elimination rate constant; PCSK9, proprotein convertase subtilisin/kexin type 9.