Table 2.
Summary of immune responses to different adjuvants on OVA nanoparticles
| Nanoparticle type | IgG1 | IgG2a | IFN‐γ | IL‐4 | CD44+/CD62L+ T cells | Affinity maturation |
|---|---|---|---|---|---|---|
| OVA‐OVA | Low | Low | No | No | No | Yes |
| OVA‐FliC | High | High | No | No | No | Yes |
| OVA‐IgM | High | High | Yes | No | Yes | No |
| OVA + soluble FliC | High | High | No | Yes | No | No |
| OVA‐FliC + OVA‐IgM | High | High | Yes | Yes | No | No |
Note. T cell responses of “Yes” and “No” have been made with respect to the PBS (G6) control. Flic = flagellin; IgM = immunoglobulin M; IgG = immunoglobulin G; OVA = ovalbumin; IFN‐γ = interferon γ; IL‐4 = interleukin 4.