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. Author manuscript; available in PMC: 2017 Jun 19.
Published in final edited form as: Nat Biomed Eng. 2016 Dec 19;1(1):0005. doi: 10.1038/s41551-016-0005

Figure 5. Long-term therapeutic efficacy of insulin-triggered adiponectin expression in insulin-resistant ob/ob mice.

Figure 5

Animals were intraperitoneally implanted with 2x106 encapsulated HEKIR-Adipo cells (200 cells/capsule). Control animals received 2x106 encapsulated pIR-/pTetR-ELK1-/pHY79-transgenic HEK-293 cells. Serum (a) adiponectin, (b) insulin (c) free fatty acid, and (d) cholesterol and (e) HOMA-IR values were determined for 20 days. (f) Food intake and (g) body-weight change were quantified on days 3 and 20. The data represent the mean ± SEM, statistical analysis using a two-tailed Student’s t-test, n=8 mice per group. *P < 0.05, **P<0.01, ***P < 0.001 vs. control.