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Tyk2 interacts with PRDM16 and PGC1-α. (A) BAT extracts from Tyk2WT TG-Cre+ or Tyk2KD TG-Cre+ mice were immunoprecipitated with Tyk2 or IgG and blotted for Tyk2, PGC1-α and PRDM16. (B) BAT extracts from Tyk2WT TG-Cre+ or Tyk2KD TG-Cre+ mice were immunoprecipitated with either PRDM16, PGC1-α, or IgG. The immunoblots were probed for Tyk2, PRDM16, or PGC1-α. IB, immunoblot; IP, immunoprecipitate (n = 3 independent experiments).
