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. 2016 Nov 7;158(1):134–147. doi: 10.1210/en.2016-1435

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Copyright © 2017 by the Endocrine Society

This article is published under the terms of the Creative Commons Attribution-Non Commercial License (CC-BY-NC; https://creativecommons.org/licenses/by-nc/4.0/).

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Figure 7. — Knockdown of Fshr with siRNA inhibits follicle growth. (A) siRNA (green) is taken up from culture medium. Nuclei are red. (B) siRNA targeted to Fshr significantly reduces follicle growth in the presence of FSH. Relative follicle areas (area at time_x/area at time₀) were compared using 1-way ANOVA with a Tukey’s multiple comparisons test (6 comparisons). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Values are means ± 95% confidence interval. Nontargeting siRNA did not significantly reduce follicle growth in the presence of FSH. (C) Follicles cultured in the presence and absence of targeted and nontargeted siRNA remain healthy. Scale bars are 25 µm.