Table 1. Characteristics of survivors by type of response; risk ratios from univariable multinomial logistic regression models.

		Total (n = 2328)		Early respondersa (n = 930)		Late respondersb (n = 671)		Non-respondersc (n = 727)		RRf early responders	95% CI	RRf late responders	95% CI
		n	%d	n	%e	n	%e	n	%e					p-valuef
Gender														<0.001
	Male	1315	56.5	455	34.6	396	30.1	464	35.3	1		1
	Female	1013	43.5	475	46.9	275	27.1	263	26.0	1.84	1.51–2.43	1.23	0.99–1.52
Age (years)														<0.001
	< 20	468	20.1	179	38,2	116	24,8	173	37,0	1		1
	20–29	1144	49.1	424	37,1	365	31,9	355	31,0	1.15	0.90–1.49	1.53	1.16–2.02
	30–39	564	24.2	258	45,7	151	26,8	155	27,5	1.61	1.21–2.15	1.45	1.05–2.01
	≥ 40	152	6.5	69	45,4	39	25,7	44	28,9	1.52	0.98–2.33	1.32	0.81–2.16
Language region of Switzerland														0.011
	German	1684	72.3	710	42,2	469	27,9	505	30,0	1		1
	French	561	24.1	189	33,7	178	31,7	194	34,6	0.69	0.55–0.87	0.99	0.78–1.25
	Italian	83	3.6	31	37,3	24	28,9	28	33,7	0.79	0.47–1.33	0.92	0.53–1.61
Nationality														<0.001
	Swiss	2017	89.3	868	43,0	602	29,8	547	27,1	1		1
	German, Austrian, French, Italiang	102	4.5	35	34,3	28	27,5	39	38,2	0.57	0.35–0.90	0.65	0.40–1.07
	Other	140	6.2	26	18,6	41	29,3	73	52,1	0.22	0.14–0.36	0.51	0.34–0.76
Neighborhood index of SEP														0.754
	First tertile (lowest SEP)	678	33.4	258	38,1	207	30,5	213	31,4	1		1
	Second tertile	678	33.4	278	41,0	186	27,4	214	31,6	1.07	0.83–1.38	0.89	0.68–1.18
	Third tertile (highest SEP)	677	33.3	265	39,1	198	29,2	214	31,6	1.02	0.79–1.32	0.95	0.73–1.25
Diagnosis (ICCC-3)														0.020
	I Leukemia	784	33.7	343	43,8	231	29,5	210	26,8	1		1
	II Lymphoma	441	18.9	154	34,9	137	31,1	150	34,0	0.63	0.47–0.83	0.83	0.62–1.12
	III CNS tumor	326	14.0	128	39,3	83	25,5	115	35,3	0.68	0.50–0.92	0.66	0.47–0.92
	IV Neuroblastoma	102	4.4	41	40,2	27	26,5	34	33,3	0.74	0.45–1.20	0.72	0.42–1.24
	V Retinoblastoma	57	2.5	19	33,3	18	31,6	20	35,1	0.58	0.30–1.11	0.82	0.42–1.59
	VI & VII Renal & hepatic tumor	152	6.5	69	45,4	49	32,2	34	22,4	1.24	0.80–1.94	1.31	0.81–2.12
	VIII Bone tumor	108	4.6	45	41,7	33	30,6	30	27,8	0.92	0.56–1.50	1.00	0.59–1.70
	IX Soft tissue sarcoma	132	5.7	52	39,4	37	28,0	43	32,6	0.74	0.48–1.15	0.78	0.48–1.26
	X Germ cell tumor	75	3.2	28	37,3	17	22,7	30	40,0	0.57	0.33–0.98	0.52	0.28–0.96
	XI & XII Other tumor	41	1.7	10	24,4	11	26,8	20	48,8	0.31	0.14–0.67	0.50	0.23–1.07
	Langerhans cell histiocytosis	110	4.7	41	37,3	28	25,5	41	37,3	0.61	0.38–0.98	0.62	0.37–1.04
Treatment														0.041
	Surgery only	289	12.6	110	38,1	66	22,8	113	39,1	0.69	0.51–0.92	0.56	0.40–0.78
	Chemotherapyh	1126	49.2	461	40,9	340	30,2	325	28,9	1		1
	Radiotherapyi	778	34.0	312	40,1	232	29,8	234	30,1	0.94	0.75–1.17	0.95	0.75–1.20
	Bone marrow transplantation	95	4.2	41	43,2	27	28,4	27	28,4	1.07	0.64–1.78	0.96	0.55–1.67
Relapse														0.540
	No	2033	87.3	819	40,3	587	28,9	627	30,8	1
	Yes	295	12.7	111	37,6	84	28,5	100	33,9	0.85	0.64–1.14	0.90	0.66–1.22
Age at diagnosis (years)														0.719
	< 5	841	36.1	346	41,1	234	27,8	261	31,0	1		1
	5–9.9	635	27.3	241	38,0	195	30,7	199	31,3	0.91	0.71–1.17	1.09	0.84–1.42
	≥ 10	852	36.6	343	40,3	242	28,4	267	31,3	0.97	0.77–1.22	1.01	0.79–1.30
Time since diagnosis (years)														<0.001
	< 10	240	10.3	84	35,0	58	24,2	98	40,8	1		1
	10–19.9	1025	44.0	380	37,1	308	30,0	337	32,9	0.76	0.55–1.05	0.65	0.45–0.93
	20–29.9	817	35.1	352	43,1	242	29,6	223	27,3	1.40	1.12–1.75	1.19	0.94–1.51
	≥ 30	246	10.6	114	46,3	63	25,6	69	28,0	1.47	1.05–2.04	1.00	0.69–1.45

^a Survivors responding to the first questionnaire sent (40.0%).

^b Survivors responding to the first reminder letter or second reminder phone call (28.8%).

^c Survivors not responding or declining participation (31.2%).

^d Column percenteges are given.

^e Row percentages are given.

^f RRs and p-values from univariable multinomial regression models comparing early and late responders with nonresponders.

^g Questionnaires were available in their mother languages (German, French, Italian).

^h Chemotherapy may include surgery.

ⁱ Radiotherapy may include chemotherapy or surgery.

Abbreviations: CI, confidence interval; CNS, central nervous system; ICCC-3, International Classification of Childhood Cancer, third edition; n, number; RR, risk ratio; SEP, socioeconomic position.