Table 1. Baseline clinical and microbiological characteristics of MDR-TB patients.
Culture Negative (n = 9) | Culture Positive Fast Responder (n = 19) | Culture Positive Slow Responder (n = 22) | P§ | ||||
---|---|---|---|---|---|---|---|
Median Age, years (IQR) | 47 | (25.5–59) | 37 | (26–45) | 27 | (22–49) | |
Female | 3 | (37.5%) | 10 | (52.6%) | 8 | (36.4%) | 0.2325 |
Prior TB Treatment | 8 | (100%) | 16 | (84.2%) | 22 | (100%) | 0.0909 |
Sputum AFB Smear | |||||||
0 or scanty | 8 | (100%) | 8 | (44.4%) | 4 | (19.0%) | 0.0707 |
1+ | 0 | - | 4 | (22.2%) | 3 | (14.3%) | |
2+ | 0 | - | 3 | (16.7%) | 2 | (9.5%) | |
3+ | 0 | - | 3 | (16.7%) | 12 | (57.1%) | |
Lung involvementa | |||||||
None | 4 | (50.0%) | 1 | (5.6%) | 0 | - | 0.4543 |
Unilateral | 1 | (12.5%) | 3 | (16.7%) | 6 | (30.0%) | |
Bilateral | 3 | (37.5%) | 14 | (77.8%) | 14 | (70.0%) | |
Cavitationa | |||||||
No | 8 | (100.0%) | 6 | (33.3%) | 2 | (10.0%) | 0.0860 |
Yes | 0 | - | 12 | (66.7%) | 18 | (90.0%) | |
BMI | |||||||
< 18.5 | 3 | (37.5% | 5 | (27.8%) | 12 | 66.7%) | 0.0888 |
18.5–24.9 | 3 | (37.5%) | 9 | (50.0%) | 5 | 27.8%) | |
25–29.9 | 1 | (12.5%) | 4 | (22.2%) | 1 | 5.6%) | |
≥ 30 | 1 | (12.5%) | 0 | - | 0 | - | |
FQN resistant | - | 3 | (15.8%) | 5 | (22.7%) | 0.4378 | |
PZA resistant | - | 12 | (85.7%) | 13 | (68.4%) | 0.2340 | |
Avg # effective drugs | |||||||
<4 | - | 18 | (94.7%) | 16 | (72.7%) | 0.1335 | |
4 to <5 | - | 1 | (5.3%) | 5 | (22.7%) | ||
5 to <6 | - | 0 | - | 1 | (4.5%) | ||
≥6 | - | 0 | 0 | - | |||
Avg # potentially effective drugs | |||||||
<4 | - | 1 | (5.3%) | 0 | - | 0.3724 | |
4 to <5 | - | 4 | (21.1%) | 3 | (13.6%) | ||
5 to <6 | - | 11 | (57.9%) | 11 | (50.0%) | ||
≥6 | - | 3 | (15.8%) | 8 | (36.4%) | ||
Months of PZA+FQN+CFZ | |||||||
<6 | - | 3 | (15.8%) | 3 | (13.6%) | 0.4778 | |
6 to 9 | - | 11 | (57.9%) | 9 | (40.9%) | ||
>9 | - | 5 | (26.3%) | 10 | (45.5%) | ||
AFB: Acid Fast Bacilli. BMI: Body mass index.
a Based on chest X-ray reviews.
§ Fast vs Slow Responders