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. 2017 May 2;12(5):e0176660. doi: 10.1371/journal.pone.0176660

Table 1. Baseline clinical and microbiological characteristics of MDR-TB patients.

  Culture Negative (n = 9) Culture Positive Fast Responder (n = 19) Culture Positive Slow Responder (n = 22) P§
Median Age, years (IQR) 47 (25.5–59) 37 (26–45) 27 (22–49)
Female 3 (37.5%) 10 (52.6%) 8 (36.4%) 0.2325
Prior TB Treatment 8 (100%) 16 (84.2%) 22 (100%) 0.0909
Sputum AFB Smear
0 or scanty 8 (100%) 8 (44.4%) 4 (19.0%) 0.0707
1+ 0 - 4 (22.2%) 3 (14.3%)
2+ 0 - 3 (16.7%) 2 (9.5%)
3+ 0 - 3 (16.7%) 12 (57.1%)
Lung involvementa
None 4 (50.0%) 1 (5.6%) 0 - 0.4543
Unilateral 1 (12.5%) 3 (16.7%) 6 (30.0%)
Bilateral 3 (37.5%) 14 (77.8%) 14 (70.0%)
Cavitationa
No 8 (100.0%) 6 (33.3%) 2 (10.0%) 0.0860
Yes 0 - 12 (66.7%) 18 (90.0%)
BMI
< 18.5 3 (37.5% 5 (27.8%) 12 66.7%) 0.0888
18.5–24.9 3 (37.5%) 9 (50.0%) 5 27.8%)
25–29.9 1 (12.5%) 4 (22.2%) 1 5.6%)
≥ 30 1 (12.5%) 0 - 0 -
FQN resistant - 3 (15.8%) 5 (22.7%) 0.4378
PZA resistant - 12 (85.7%) 13 (68.4%) 0.2340
Avg # effective drugs
<4 - 18 (94.7%) 16 (72.7%) 0.1335
4 to <5 - 1 (5.3%) 5 (22.7%)
5 to <6 - 0 - 1 (4.5%)
≥6 - 0 0 -
Avg # potentially effective drugs
<4 - 1 (5.3%) 0 - 0.3724
4 to <5 - 4 (21.1%) 3 (13.6%)
5 to <6 - 11 (57.9%) 11 (50.0%)
≥6 - 3 (15.8%) 8 (36.4%)
Months of PZA+FQN+CFZ
<6 - 3 (15.8%) 3 (13.6%) 0.4778
6 to 9 - 11 (57.9%) 9 (40.9%)
>9 - 5 (26.3%) 10 (45.5%)
             

AFB: Acid Fast Bacilli. BMI: Body mass index.

a Based on chest X-ray reviews.

§ Fast vs Slow Responders