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. 2016 Nov 21;158(2):293–303. doi: 10.1210/en.2016-1393

Figure 5.

Figure 5.

(A) Nonfasting blood glucose levels in 6- to 8-week-old db/+;+/+ (circles) or db/db (triangles) mice treated with (open symbols) or without (solid symbols) the antihyperglycemic agent phlorizin. (B) Nos3 islet protein levels after the 2-week treatment period with vehicle (Veh)-treated mice shown in open bars and phlorizin (Phz)-treated mice shown in solid bars. Representative western blots showing Nos3 and β-actin protein levels are shown above the bar graph; n = 5 to 6; *P < 0.05 vs all other treatment groups. (C) Islet mRNA levels of endothelial markers in C57BL/6J mice fed a low-fat (open bars) or high-fat (solid bars) diet from 10 to 28 weeks of age; n = 9 to 10 for mRNA; *P ≤ 0.05 vs low-fat control. (D) Islet Nos3 protein in islets from low-fat (open bar) and high-fat (solid bar) fed mice; n = 7. Representative western blots for Nos3 and β-actin protein levels shown above the bar graph.