Table 1.

vWf response to shear stress

Shear stress range (Pa)	Exposure time (s)	Consequences	Reference
3.7	12	Enhanced cleavage of vWf multimer	[22]
6.5	∼0.2 (repetitive)	Reduction in high molecular weight multimers in patients with aortic stenosis	[23]
10	—	Stress required to unfold the functional domain	[25]