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. 2016 Nov 14;102(2):499–506. doi: 10.1210/jc.2016-2342

Table 2.

Associations of Birth Weight and Cord Blood Analyte With Fat Mass, Waist Circumference and BMI z Scores, and Obesity Outcome at Age 9 Years

Exposure Outcome Fat Mass z Scorea
Waist Circumference z Score
BMI z Score
Obesity
Coefficient 95% CI P Coefficient 95% CI P Coefficient 95% CI P OR 95% CI P
Leptin, per 10 pg/mL Model 1 0.07 0.04, 0.10 <0.001 0.08 0.05, 0.12 <0.001 0.11 0.07, 0.15 <0.001 1.15 1.00, 1.31 0.046
Model 2 0.04 0.00, 0.07 0.023 0.05 0.01, 0.08 0.008 0.06 0.02, 0.10 0.003 1.00 0.85, 1.17 0.993
Model 3 0.03 0.00, 0.06 0.086 0.04 0.00, 0.07 0.045 0.04 0.00, 0.08 0.029 0.95 0.81, 1.12 0.548
Adiponectin, per 10 µg/mL Model 1 0.00 −0.01, 0.01 0.828 −0.01 −0.02, 0.00 0.072 0.00 −0.02, 0.01 0.602 0.99 0.94, 1.05 0.845
Model 2 0.00 −0.01, 0.01 0.916 −0.01 −0.02, 0.00 0.118 0.00 −0.01, 0.01 0.858 1.00 0.94, 1.05 0.874
Model 3 0.00 −0.01, 0.01 0.875 −0.01 −0.02, 0.00 0.100 0.00 −0.01, 0.01 0.767 0.99 0.94, 1.05 0.834
Birth weight, per 100 gb Model 1 0.01 0.00, 0.02 0.006 0.03 0.03, 0.04 <0.001 0.04 0.03, 0.05 <0.001 1.06 1.02, 1.10 0.006
Model 2 0.00 0.00, 0.01 0.192 0.03 0.02, 0.04 <0.001 0.04 0.03, 0.04 <0.001 1.03 0.99, 1.07 0.193
Model 3 0.00 −0.01, 0.01 0.741 0.02 0.02, 0.03 <0.001 0.03 0.02, 0.04 <0.001 1.01 0.96, 1.05 0.852

For this study, N= 2775. Model 1 was adjusted for offspring sex and age at measurement. Model 2 was adjusted for offspring sex, age at measurement, and maternal confounders (age, smoking, parity, occupational social class, education, and prepregnancy BMI). Model 3 was adjusted for offspring sex, age at measurement, and maternal confounders plus pregnancy confounders (gestational age at birth, mode of delivery, gestational weight gain, hypertensive disorders, and diabetic disorders of pregnancy).

Abbreviations: CI, confidence interval; OR, odds ratio.

a

Fat mass adjusted for height.

b

Birth weight adjusted for sex, gestational age, and singleton/twin pregnancy.