Figure 6.
Inhibition of KCa2 channels in the PrL-PFC does not alter extinction of alcohol-seeking behavior. A, Alcohol consumption during the maintenance phase of the self-administration procedure. B, Mean number of lever presses and reinforcers (Reinfs) after a history of operant alcohol self-administration. C, Mean active lever presses during extinction learning sessions after daily PrL-PFC microinjections of the KCa2 channel inhibitor apamin (0 and 10 μm). D, Mean number of sessions to reach extinction criteria after vehicle or apamin microinjections. E, Diagram of coronal rat brain sections showing the location of microinjector tips (dark circles) in the PrL-PFC. Illustrations were adapted from the atlas of Paxinos and Watson (2005). Numbers along the left side of each section represent the distance (in millimeters of that section from bregma; n = 6 per treatment group). Values are expressed as group means ± SEM.