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Average lifespan after onset of symptoms. POLG syndromes are progressive conditions, and age of onset correlates directly with the severity of the disease. Patient data were analyzed in cases for which both the age of onset of symptoms and age of death were reported, and included 144 patient cases. The use of valproic acid to treat patients with epileptic seizures may account for shortened lifespans in the data in the more severe cases of POLG syndromes.
