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. 2017 Jan 28;4(1):1–17. doi: 10.1016/j.jcmgh.2017.01.011

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Gluten-dependent intestinal mucosal injury as a clinical end point in a human clinical study. Vh:Cd, a histologic measure of mucosal health, was determined at baseline and at the 6-week time point. ΔVh:Cd, defined as baseline minus the 6-week Vh:Cd, represents intestinal damage (positive number) or healing (negative number) over the 6-week timeframe. The bar graph shows the number of patients (y-axis) with a given ΔVh:Cd (x-axis) for a total of 73 patients. The number of patients for a given ΔVh:Cd was subdivided further to indicate the amount of gluten ingested daily per patient, which was 6 (blue, 20 patients), 3 (yellow, 26 patients), and 1.5 (grey, 27 patients) grams of gluten daily for 6 weeks.