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Serial MRI studies in Patient 1 (upper panels). A second brain MRI obtained 16 days after admission (panel B) showed the development of diffuse brain atrophy as compared with first brain MRI obtained on admission (panel A). Brain MRI obtained 6 months after admission showed the further progression of diffuse brain atrophy (panel C). Fourteen years after admission, the diffuse brain atrophy had partially improved (panel D).
