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. 2017 May 1;214(5):1239–1248. doi: 10.1084/jem.20161033

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© 2017 Deeg et al.

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Figure 5. — hMx-tg mice exhibit only moderate resistance to influenza A viruses of human origin. (A) Groups of hMx-tg^+/− and non-tg mice were challenged by the i.n. route with ∼10 LD₅₀ (high dose; values refer to non-tg mice) of mouse-adapted influenza A virus strains of human origin, namely A/WSN (5 × 10³ pfu; seven hMx-tg^+/− and six non-tg), A/PR8 (10⁴ pfu; seven animals each) or A/HK68 (100 pfu; five hMx-tg^+/− and nine non-tg). (B) Other groups of transgenic and nontransgenic mice were challenged with 2–3 LD₅₀ (low dose) of A/WSN (1.3 × 10³ pfu; eight hMx-tg^+/− and nine non-tg), A/PR8 (3 × 10³ pfu; six animals each) or A/HK68 (30 pfu; five hMx-tg^+/− and seven non-tg). Weight loss was monitored daily; animals were sacrificed and scored dead when weight loss reached the 25% limit. (C) Groups of hMx-tg^+/− and non-tg mice were infected with 10⁴ pfu of human influenza virus strains WSN, Udorn or HH. Viral titers in the lungs at day 4 after infection are shown. ***, P < 0.0005; ****, P < 0.0001, Student’s t test.