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. 2017 May 1;214(5):1313–1331. doi: 10.1084/jem.20161076

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© 2017 Kitada et al.

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Figure 3. — Severe multiorgan pathology in T. cruzi–infected Batf2^−/− mice. (A and B) Representative histopathology (A) and histopathological score (B) of wild-type (n = 8) and Batf2^−/− (n = 9) mice 49 d after infection. Bars, 100 µm. Graphs show mean values ± SD. *, P < 0.01. (C) Concentrations of AST and CK in the plasma and CRE in tge sera of T. cruzi–infected wild-type (n ≥ 14) and Batf2^−/− (n ≥ 19) mice. *, P < 0.05; **, P < 0.01. Graphs are mean values ± SEM. (D) Mpo expression in tissues of wild-type and Batf2^−/− mice after T. cruzi infection (n = 3 per group). *, P < 0.05; **, P < 0.02. Data are mean values ± SEM. (E) Expression of Th17-related genes (n = 4 per group). *, P < 0.05; **, P < 0.02; n.s., not significant. All graphs show mean values ± SEM.