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. 2017 May 1;214(5):1313–1331. doi: 10.1084/jem.20161076

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© 2017 Kitada et al.

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Figure 7. — Reduced CD4⁺ T cell IL-17 production in T. cruzi–infected Batf2^−/−Il23a^−/− mice. (A–D) Wild-type (n = 18), Batf2^−/− (n = 12), Il23a^−/− (n = 9), and Batf2^−/−Il23a^−/− (n = 9) mice were infected with T. cruzi for 20 d. CD4⁺ T cells were isolated from the spleen of T. cruzi–infected mice and stimulated with anti-CD3 antibody (A and C) or freeze-thawed T. cruzi in the presence of antigen-presenting cells (B and D) for 24 h. The culture supernatants were analyzed for IFN-γ (A and B) and IL-17 (C and D) by ELISA. ^#, P < 0.045; ^##, P < 0.006. (E) Expression of Il17a and Il22 in CD4⁺ T cells from the livers of T. cruzi–infected mice. ^#, P < 0.05. (A–E) Graphs show mean values ± SEM.