Figure 8.
IL-23–mediated immunopathology in Batf2−/− mice during T. cruzi infection. (A) Parasite equivalents in the livers, hearts, and blood of T. cruzi–infected wild-type (n = 18), Batf2−/− (n = 12), Il23a−/− (n = 9), and Batf2−/−Il23a−/− (n = 9) mice (mean values ± SEM). #, P < 0.05. (B) Representative sections (top) and pathological score (bottom) in T. cruzi–infected mice. Data are mean values ± SEM. Bars, 100 µm. *, P < 0.009; **, P < 0.006. (C) Concentrations of AST and CK in the plasma and CRE in the sera of T. cruzi–infected mice. Data are mean ± SEM. #, P < 0.05; ##, P < 0.01.