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. 2017 May 1;214(5):1297–1311. doi: 10.1084/jem.20161141

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© 2017 Choo et al.

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Figure 1. — BA VB and spores induce differential gene expression in macrophages via distinct microbial sensing mechanisms. (A–E) WT mouse macrophages (A, B, and D), macrophages from the indicated mice (C and E), or WT mouse plasmacytoid DCs (pDC; D) were exposed to VB or spores (Sp) of BA at moi of 3 (A–C and E) or at the indicated moi (D). Whole-cell lysates were prepared at the indicated time points (A) and 24 h (B) after exposure, and analyzed by immunoblotting. Relative mRNA amounts for VB/Sp-induced genes at the indicated time points (C) or 4 h (D and E) after exposure were determined by qPCR, and presented in color-coded arbitrary units (C) or plotted on a linear scale (D and E). ISG, IFN-stimulated gene. Data are representative of two experiments with similar results (A, B, D, and E) or from one experiment (C).