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. 2017 May 1;214(5):1297–1311. doi: 10.1084/jem.20161141

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© 2017 Choo et al.

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Figure 9. — Type I interferon signaling is detrimental to host resistance to BA. (A) Macrophages from the indicated mice were exposed to BA spores at moi of 3. Relative RNA amounts for spore-induced genes at the indicated time points after exposure were determined by qPCR, and plotted on a linear scale. (B–E) The indicated mice were infected with BA (10⁷ and 2.5 × 10⁶ cfu per host; B and C–E, respectively) by footpad injection of spores. Host survival (n = 15–19 mice per group) was monitored for 10 d (B). Bacterial burdens in popliteal lymph nodes (C), footpad swelling (D), and serum concentrations of IL-1β (E) were determined 3 d after infection. Data are from one experiment (A and E) or representative of two experiments with similar results (B–D). *, P < 0.05; ***, P < 0.001; Log-rank test (B) and Student’s t test (C).