Table 1.
Patient characteristics at time of HCT
| UPN | Age at HCT | Gender | Ethnicity | Gene mutation | CD3 | CD4 | CD8 | CD19 | CD16/56 | PHA (%) | TME | Indication for HCT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| (× 106/L) | ||||||||||||
| Newly diagnosed | ||||||||||||
| 1509 | 4 month | M | Hispanic | RAG-1 (c.1181G>A + c.1951T > C) | 14 | 14 | 0 | 0 | 258 | 0 | 0 | Rotavirus |
| 1533 | 6 month | M | Caucasian | IL2RG (c.858 Splice Site) | 8898* | 214 | 750 | 1822 | 214 | 0 | 45 | PCP, rotavirus |
| 1535 | 2 month | F | Hispanic | IL-7R (c.212T>C + c.539A > C) | 111 | 95 | 0 | 340 | 308 | 0 | 1 | None (NBS) |
| 1591 | 2 month | M | Hispanic | IL2RG (c.822_840del19) | 0 | 0 | 0 | 1096 | 45 | 0 | 0 | None (NBS) |
| Boost transplants | ||||||||||||
| 1056† | 6 yr | M | Caucasian | IL2RG (c.31T > A) | 334 | 188 | 127 | 103 | 28 | 43 | NA | Severe molluscum |
| 1057† | 6 yr | M | Caucasian | IL2RG (c.31T > A) | 437 | 90 | 325 | 106 | 17 | 51 | NA | Severe molluscum |
| 237 | 15 yr | F | Navajo | Artemis (c.597C > A) | 451 | 209 | 242 | 0 | 99 | 34 | NA | FTT |
UPN, unique patient number; PHA, phytohemagglutinin; TME, transplacental maternal engraftment; RAG, recombinase-activating gene; PCP, Pneumocystis jiroveci pneumonia; NBS, newborn screen; FTT, failure to thrive; NA, not applicable.
*
T cells primarily of maternal origin.
†
UPN 1056 and 1057 were identical twins.