Fig. 5.

Cytokine release from human phagocytic cells (THP-1, human monocytes; U937, human myeloid cells; and PMNs purified from human blood) exposed to buffer (negative control) or individual histones (50 µg/mL, 4 h, 37°C) followed by cytokine analysis by ELISA of supernatant fluids. Each bar represents at least 4 separate experiments. The cell number for each sample was 1 × 10⁶/mL. * p < 0.05.