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Cytokine release from mouse peritoneal macrophages from TLR2−/−, TLR4−/−, and TLR2,4−/− exposed to purified histones compared to Wt. Cytokine responses of PEMs including TNF (a), IL-6 (b), and IL-1β (c) in mouse PEMs from Wt, TLR2−/−, TLR4−/−, and double TLR2,4−/− mice. Macrophages (1 × 106/mL) were incubated with buffer (negative control) or with purified histone (50 µg/mL) for 4 h at 37°C. Each bar represents at least 5 separate experiments.
