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Ability of individual histones to induce ALI (by i.t. instillation of purified histones, 100 µg). BALFs were collected for analysis at 8 h following i.t. instillation of individual histones into the lungs. a Mouse albumin content as assessed by ELISA. b PMN accumulation in BALFs. For each bar, n = 5 separate mice measured using standard microscopy for the enumeration of cells. All mediators were measured by ELISA in BALF cytokines (c–e) and chemokines (f–h). * p < 0.05.
