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. Author manuscript; available in PMC: 2018 May 1.

Published in final edited form as: J Bone Miner Res. 2017 Jan 19;32(5):1082–1089. doi: 10.1002/jbmr.3068

Table 2b.

Multivariable age- and sex-stratified Cox models of the HR for fracture associated with AN adjusted for antidepressant and alcohol use

	Females		Males

	HR (95% CI) ^a	P	HR (95% CI) ^a	P
Age ≤40 years
AN	1.49 (1.32, 1.68)	<0.001	0.74 (0.48, 1.15)	0.18
Antidepressant use	1.51 (1.36, 1.68)	<0.001	1.47 (0.98, 2.20)	0.06
Alcohol abuse	2.75 (1.90, 3.99)	<0.001	1.76 (0.65, 4.78)	0.26
Age >40 years
AN	1.31 (1.10, 1.56)	0.002	2.21 (1.11, 4.42)	0.02
Antidepressant use	1.46 (1.28, 1.67)	<0.001	1.20 (0.56, 2.55)	0.64
Alcohol abuse	2.55 (1.72, 3.78)	<0.001	6.49 (2.26, 18.58)	<0.001

^a

HR refers to fully adjusted model including AN, antidepressant use and alcohol abuse