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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: J Bone Miner Res. 2017 Jan 30;32(5):892–901. doi: 10.1002/jbmr.3038

Figure 3. The effect of Scl-Ab on BrdU incorporation and osteogenic activity.

Figure 3

(A) The levels of serum P1NP for Dmp1-CreERt2:Rosa26R mice receiving Scl-Ab or vehicle treatment for 1 week. Data are expressed as mean ± SD, n = 4; a: p < 0.05 versus 12w or 13w_vehicle.

(B) BrdU incorporation analysis for Dmp1-CreERt2:Rosa26R mice receiving Scl-Ab or vehicle treatment for 1 week. BrdU staining of paraffin sections of the femur was performed (middle panel). No X-gal (+) cell shows BrdU staining. (C) The mean number of BrdU-positive cells (arrows in panel B) was determined in 3–4 comparable sections, viewing 9–12 fields/section under 400× from four mice per each group (right panel). Data are expressed as mean ± SEM. Data are representative of experiments performed on sections from three mice for each group.