TABLE1: Diagnostic Criteria of WM and Differential Diagnosis

Waldenstrom Macroglobulinemia1	Smoldering Waldenstrom Macro globulinemia1	IgM MGUS1	Multiple Myeloma	Marginal Zone Lymphoma
1. IgM monoclonal gammopathy of any concentration. 2. BM infiltration by small lymphocytes with plasmacytoid or plasma cell differentiation≥10% 3. Intertrabecular patterns of BM infiltration. 4. Surface marker - Positive: IgM, CD19, CD20, CD22, CD25, CD27, FMC7 - Negative: CD10, CD23, CD103, CD138 5. Presence of symptoms	1. Meet the criterial of WM 2. Absence of symptoms, anemia, organomegaly, lymphadenopathy, or hyperviscosity	1. Serum IgM monoclonal protein <3000mg/L 2. BM lymphoplasmacytic infiltration <10% 3. No evidence of end-organ damage, anemia, hyperviscosity, lymphoadenopathy, or hepatosplenomegaly from the underlying lymphoproliferative disorder.	1. Clonal BM plasma cell ≥ 10% or biopsy proven plasmacytoma and at least one of the myeloma defining events - Hypercalcemia with serum Ca >0.25mmol/L higher than the upper normal limit or >2.75mmol/L - Renal impairment with CrCl < 40ml/min or serum Cr > 2mg/dL - Anemia with Hb <100g/L or more than 20g/L below than lower normal limit - Osteolytic bone lesions on skeletal radiography, CT, or PET/CT	1. Polymophous small cell infiltration with associated reactive appearing follicles. 2. Positive for B-cell markers including CD19, CD20, CD22. 3. Negative for CD5, CD10, and CD23. 4. Presence of trisomy3 or t(11;18)