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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Clin Cancer Res. 2016 Nov 3;23(9):2325–2334. doi: 10.1158/1078-0432.CCR-16-1323

Figure 3. NNMT silencing sensitizes GBM cells to radiation treatment, decreases proliferation and colony forming ability.

Figure 3

(A) The MTT assay was used to calculate the relative proliferation rate of the NNMT isogenic cell lines relative to the U87-WT cell line.

(B) Growth inhibition of the NT and KD cell lines following radiation and temozolomide treatment.

(C) The growth inhibition of KD and NT cells following 6 Gy radiation over a 12 day period.

(D) Clonogenic survival curves of the NNMT isogenic cell lines. Representative pictures of the clonal cells used to calculate the colonies and plot the survival curve have also been provided.

(E) Western blot analysis of the basal levels of NNMT and cleaved caspase 3.