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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Clin Cancer Res. 2016 Nov 3;23(9):2325–2334. doi: 10.1158/1078-0432.CCR-16-1323

Figure 6. NNMT silencing decreases the methylation potential and schematic illustration.

Figure 6

(A) Western blot analysis was used to determine the change in PP2A methylation/activation following different concentrations of PPZ and OA in the WT, KD, and OE cell lines.

(B) Western analysis of NNMT expression and Akt and p44/42 MAPK activation following the addition of OA with and without the addition of PPZ.

(C) A schematic illustrating the in cancer cells, the upregulation of NNMT utilizes an increased amount of SAM, directly modulating the expression of pro-survival kinases by influencing the activation of phosphatases.