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In vivo tumor inhibition study. (a) Balb/c nude mice were injected with PBS, free paclitaxel (PTX) and hyaluronic acid (HA)-cholanic acid (CA)-PTX at Day 0 (n = 3). Comparison of tumor size on Day 8 of (b) Control, (c) PTX, (d) HA-CA-PTX (2 mg/kg), and (e) HA-CA-PTX (5 mg/kg). Tumor inhibition data show mean tumor volume, of triplicate samples ± SD. *P <0.05 relative to HA-CA-PTX (2 mg/kg) and **P <0.05 relative to control group. Reproduced, with permission, from [72].
