Table 1.

Examples of recently published research that utilizes HA as a targeting moiety

Type of cancer	Polymer	Drug	% Loading	Micelle diameter	Target cell line	Refs
Breast cancer	Hexadecylamine	Docetaxel	8–16%	150	MDA-MB-231	[61]
	Dendritic oligoglycerol	PTX	20%	155	MCF-7	[62]
	DOCA	PTX	34%	120	MDA-MB-231	[63]
	Phosphorylcholine	DOX	10.40%	186	MDA-MB-231	[74]
	Hydrophobic poly(L-histidine) (PH19)	DOX	6.77%	215	MCF-7	[50]
	Hydrophobic poly(L-histidine) (PH22)	DOX	6.06%	173	MCF-7	[50]
	Hydrophobic poly(L-histidine) (PH28)	DOX	4.23%	154	MCF-7	[50]
	Adipic dihydrazide	Quercetin	–	172.1	MCF-7	[55]
	DOCA	PTX	34.10%	–	MDA-MB-231	[52]
	Octadecyl-grafted HA/folic acid	PTX	–	–	MCF-7	[82]
	Polypropylene glycol	DOX	2.20%	–	MCF-7	[100]
Liver cancer	Histidine/glycyrrhetinic acid	DOX	8.64%	162	HepG2	[72]
	Poly(D,L-lactide-co-glycolide) amine	Docetaxel	5–11%	50–200	HepG2	[51]
Pancreatic cancer	Copoly (styrene maleic acid)	CDF	15.50%	114	MiaPaCa-2& AsPC-1	[53]
Head and neck cancer	Poly(pyridyl disulfide methacrylate)	DOX	8.70%	–	SCC7	[76]
	CA	PTX	10%	–	SCC7	[70]