Table 1.
Characteristics of endometrial cancer cases from the Nurses’ Health Study
| Characteristic | All Cases (n=2,035) | Received Any Tumor Tissue (n=472) | In Tissue Microarrays (n=360) | |||
|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | |
| Age (years) | 63.5 | 8.9 | 68.2 | 7.6 | 69.0 | 7.3 |
| Years from Menarche to Menopause | 38.3 | 4.5 | 38.9 | 4.3 | 38.9 | 4.1 |
| Years Since Menopause | 12.8 | 9.0 | 17.1 | 8.7 | 17.7 | 8.5 |
| E-only HT Use of ever users (years)a | 5.5 | 5.0 | 4.8 | 4.7 | 5.1 | 4.9 |
| E+P HT Use of ever users (years)a | 5.3 | 4.3 | 5.9 | 5.0 | 6.2 | 5.0 |
| Other HT Use of ever users (years)b | 5.4 | 12.0 | 5.1 | 7.3 | 5.1 | 8.1 |
| OC Use of ever users (years) | 4.3 | 8.0 | 3.5 | 3.6 | 3.6 | 3.7 |
| Pack-Years Smoking | 11.5 | 18.2 | 11.0 | 17.3 | 11.6 | 17.7 |
| Parity among parous | 3.0 | 1.4 | 2.9 | 1.4 | 3.0 | 1.4 |
| N | % | N | % | N | % | |
| Year of Diagnosis | ||||||
| 1976–1985 | 324 | 16 | 2 | 0 | 0 | 0 |
| 1986–1995 | 642 | 32 | 51 | 11 | 34 | 9 |
| 1996–2005 | 757 | 37 | 249 | 53 | 190 | 53 |
| 2006–2013 | 311 | 15 | 170 | 36 | 136 | 38 |
| Race | ||||||
| White | 1,995 | 98 | 467 | 99 | 356 | 99 |
| African-American | 22 | 1 | 3 | 1 | 2 | 1 |
| Native American | 4 | 0 | 0 | 0 | 0 | 0 |
| Asian | 14 | 1 | 2 | 0 | 2 | 1 |
| Hispanic Ethnicity | 9 | 0 | 1 | 0 | 0 | 0 |
| Body Mass Index (kg/m2) | ||||||
| Normal Weight (<25) | 627 | 34 | 132 | 30 | 97 | 29 |
| Overweight (25<=BMI<30) | 562 | 30 | 137 | 31 | 109 | 32 |
| Obese (>=30) | 654 | 35 | 176 | 40 | 134 | 39 |
| E-only HT never users | 1,512 | 74 | 371 | 79 | 281 | 78 |
| E+P HT never users | 1,515 | 74 | 310 | 66 | 238 | 66 |
| Other HT never users | 1,384 | 68 | 288 | 61 | 224 | 62 |
| OC never users | 1,279 | 63 | 273 | 58 | 208 | 58 |
| Nulliparous | 158 | 8 | 40 | 9 | 28 | 8 |
| Smoking Status | ||||||
| Never Smoker | 1,013 | 50 | 228 | 48 | 170 | 47 |
| Former Smoker | 821 | 40 | 227 | 48 | 177 | 49 |
| Current Smoker | 201 | 10 | 17 | 4 | 13 | 4 |
| Diabetic | 199 | 10 | 59 | 13 | 48 | 13 |
| Family History of Endometrial Cancer | 158 | 8 | 28 | 6 | 22 | 6 |
| Tumor Stage | ||||||
| I | 1,706 | 88 | 405 | 87 | 313 | 87 |
| II | 65 | 3 | 20 | 4 | 18 | 5 |
| III | 39 | 2 | 7 | 2 | 5 | 1 |
| IV | 139 | 7 | 36 | 8 | 23 | 6 |
| Tumor Histologic Type | ||||||
| Endometrioid | 1,902 | 94 | 457 | 97 | 349 | 97 |
| Non-Endometrioid | 113 | 6 | 15 | 3 | 11 | 3 |
| Tumor Grade | ||||||
| Well-Differentiated | 988 | 53 | 234 | 51 | 178 | 51 |
| Moderately-Differentiated | 594 | 32 | 140 | 31 | 109 | 31 |
| Poorly-Differentiated | 291 | 16 | 85 | 19 | 65 | 18 |
Variables are as of time of endometrial cancer diagnosis.
a
Orally-ingested pills only.
b
Includes E-only, E+P, and progesterone-only vaginal creams, as well as progesterone-only orally-ingested pills E-only=Unopposed Estrogen, E+P=Estrogen+Progesterone, HT=Hormone Therapy, OC=Oral Contraceptive