Table 1.

Regulation of NF-Y dependent gene expression by various specific cell types or signaling linked to normal development or pathogenic conditions

Genes	Cell type	Signaling	Normal/Pathophysiology	References
Type I collagen (COL1A1, COL1A2)	Fibroblasts	TGF-beta, Mechanical strain	Systemic sclerosis, Fibrosis, Hypertension	4, 36, 37
Dentin Sialophospho protein (DSPP)	Odontoblasts	BMP2	Tooth development	39
SOX9	Chondrocytes	BMP2	Cartilage development	40
HOXB4	Hematopoietic stem cells (HSC)	HSC self- renewal	Hematopoiesis	46
Major histocompatibility class II	B cells	Interferon- gamma	Immune response	10, 11
Tet 1/2	T regulatory cells	Inflammatory response	Immune homeostasis	47
OCT4/Nanog/Prdm14	Embryonic stem cells (ESC)	ESC identity	Early development	50
TopoIIalpha, CCNB1, CCNB2, CDC25C, and other cell cycle regulated genes	Cancer cells	Cell cycling, Oncogenic signaling by wild-type and mutant p53	Cell proliferation, DNA damage response, Cancer progression	12– 18, 21–23
GRP78, GRP94, PDI, and other endoplasmic reticulum (ER) chaperones	Hepatocytes, Islet beta-cells, Neuronal cells, Various secretory cells	Unfolded protein response or ER stress mediated by ATF6 activation	Genetic disorders associated with protein misfolding, Metabolic disease, Neurodegenerative disease, Diabetes	5, 6, 19, 20, 24–26, 44, 45
HMG-CoA synthase, SQLE, DHCR24, and other Cholesterol biosynthesis genes, and FASN, SCD, and lipid biosynthesis genes	Hepatocytes, Adipocytes, Various lipogenic cells	Sterol balance, nutritional response mediated by SREBP1 activation	Metabolic syndrome, Hepatosteatosis, Lipotoxicity associated disease	7– 9, 27, 28