Table 2.

Final proteomic peaks identified after random forest feature selection and optimization for each time period, separately

	Feature Selection	Optimization
Time Intervala (yrs.)	protein peaks (m/z)	protein peaks (m/z)	Sensitivity/Specificity	Error rate
1	3288.69, 2818.53, 3119.32, 2886.67, 2835.08, 3257.54, 2939.23, 5078.81, 4227.07, 5621.97, 3579.74	3119.32, 2886.67, 2939.23, 5078.81	0.691 / 0.673	0.318
2	4247.51, 1999.89, 2754.29, 6186.56, 5427.29	4247.51, 2754.29, 6186.56, 5427.29	0.652 / 0.370	0.489
3	6004.53, 2285.10	6004.53, 2285.10	0.452 / 0.548	0.500
4–5	3682.93, 2522.61, 2506.06, 2909.06, 3523.29, 4247.51, 3642.04, 2080.68, 2133.24	2909.06, 4247.51, 2080.68	0.308 / 0.590	0.551
6–8	3650.80, 2818.53, 4185.21, 4339.98, 3443.46, 3086.22, 2273.42, 5671.62, 4518.12, 2313.33, 2990.83, 2583.94, 3097.90, 7186.26, 5471.09, 2430.14, 3257.54, 3241.97	2990.83	0.500 / 0.344	0.578
8+	4128.75, 2293.86, 3147.55, 4339.98, 5804.00, 4185.21, 7562.00, 2835.08, 4247.51, 6785.21, 3916.55, 5015.53, 6186.56	3147.55, 4185.21, 7562.00, 6186.56	0.612 / 0.510	0.439

Note: Unique samples from matched case-control pairs with case confirmation in ACTUR were used

^aTime before cancer diagnosis (cases) or reference date (controls)