Table 3.
Model optimization with additional epidemiologic information from the Serum Repository (SR) or questionnaire data for selected proteomic peaks in the year before cancer diagnosis
| Model | Error rate | Sensitivity/Specificity | Final variablesa |
|---|---|---|---|
| SR | 0.33 | 0.691 / 0.655 | 3119.316895 |
| 2886.669922 | |||
| 2939.234619 | |||
| 5078.806641 | |||
| Adenovirus vaccine | |||
| Anthrax vaccine | |||
| Influenza H1N1 vaccine | |||
| SR + Q (bfbd) | 0.28 | 0.680 / 0.760 | 3119.316895 |
| 2886.669922 | |||
| 2939.234619 | |||
| 5078.806641 | |||
| Other cancer | |||
| Tonsillectomy | |||
| SR + Q (diag) | 0.28 | 0.760 / 0.680 | 3119.316895 |
| 2886.669922 | |||
| 2939.234619 | |||
| 5078.806641 | |||
| Smoking at diagnosis |
SR= Serum Repository; Q=questionnaire; bfbd=before first blood draw; diag=before diagnosis
a
Peaks included in each model are from time period 1 in Table 2